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Cardarine

Discussion in 'Other PED's and POM's' started by huntingground, Oct 8, 2019.

  1. huntingground

    huntingground Kenstradamus Competitor

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    Chaps,

    I've been on Cardarine (20mg per day) for 3 months solid and absolutely love the compound. I'd like to stay on forever.

    What are your experiences with Cardarine?

    Post up any lab studies on Cardarine too. I know the carcinogenic angle but that study was on rodents at massive dosages (unpublished unfortunately).

    https://spiral.imperial.ac.uk/bitstream/10044/1/65136/7/Dear Editor_V_upload_spirall.pdf

    However, there is cause for concern regarding at least one drug that activates PPARβ/δ, GW501516, developed by GlaxoSmithKline plc (GSK) in the early 2000’s. Despite these concerns and although not confirmed in humans, following the publication of endurance exercise studies in rodents, a significant underground market has developed for unlicensed GW501516 (also referred to as Endurobol or Cardarine) in a bid to enhance human athletic performance. Of particular relevance are two abstracts from GSK showing that GW501516 causes cancer in rats (6) and mice (7) after 104 weeks of dosing. Although, neither of these studies has been published as full peer reviewed papers these abstracts have been very influential. The phase 4 trial (NCT00841217) was stopped and warnings issued by the World Anti-Doping Agency(8), Health Canada (9) and most recently in April 2018 GW501516 was classified as a poisonous substance in Australia (10). The precise role of PPARβ/δ in cancer, particularly in humans however remains unclear, as reports continue to emerge showing that agonists may either increase or protect against different cancers(11).

    https://academic.oup.com/carcin/article/28/12/2641/2476288/

    Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) ligands do not potentiate growth of human cancer cell lines

    https://www.sciencedirect.com/science/article/pii/S0300483X08004472

    Results from this study demonstrate that two human lung cancer cell lines respond to ligand activation of PPARβ/δ by modulation of target gene expression (Angptl4), but fail to exhibit significant modulation of cell proliferation.

    https://clinicaltrials.gov/ct2/show/NCT00841217?term=NCT00841217&rank=1


    Essentially, there are no published studies on humans and Cardarine has been removed from trials due to the possibility of proliferation of cancerous cells.
     
    #1
  2. noel

    noel Moderator

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    made me feel sick after a few days when i tied it

    so its off my menu.

    mixed bag on pros and cons, says cancerous in some ways, might help in others, might help lipids, might help cardio....

    nothing in there that wows me to be fair to add it on top of other stuff
    regardless of rat dose if GsK didnt want to pursue it for that reason , thats good enough for me to not use for now, given the limited upside , improved lipids use Citrus Bergamot, feel better do a bit of cardio, for stength or performance you have tbol, anavar etc
     
    Last edited: Oct 8, 2019
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  3. Porky

    Porky Committee brofessor Top Contributor

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    The LD50 is 2000mg/kg bw, so safe to say it's hard to od on it
     
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  4. Greedy Ben

    Greedy Ben Top Contributor

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    I did 20mg/day for about 8wks pre holiday last year on 'cruise' endurance and gym performance was significantly increased, increased vascularity too - I did slim down a bit too but that was obv mainly the diet.
    My mrs took the same amount too and felt the same benefits.
    2 wks into our holiday and post taking it there was a noticable drop off in cv and we both felt 'yep it's def gone now'

    Currently using with 20mg ostarine too but have only been on it a wk so won't be working to full extent.


    https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/gw501516

    Bit heavy but shows potential benefits

    https://www.frontiersin.org/articles/10.3389/fphar.2018.00648/full

    This article shows it being tested directly on human cancer cells and it did not increase the growth rate - from what I can make out of it. Seen similar too.


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614479/
     
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  5. flash

    flash Top Contributor

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    Never even heard of it
     
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  6. Guest

    Guest Guest

    Only for the ones who take it srs
     
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  7. noel

    noel Moderator

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    5 quid a tab, PM me for details, if Ken the genetic phenom uses, you know it must be gold
     
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  8. flash

    flash Top Contributor

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    Haha fuck that then
     
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  9. flash

    flash Top Contributor

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    I’ll stick to the Tren/Dnp/Slin triple threat combo us natty amateurs use
     
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  10. Greedy Ben

    Greedy Ben Top Contributor

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    #10
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  11. mal

    mal Top Contributor

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    Not used it for long, but i look a bit leaner and less bloated on it...does give more energy during workout i think..
     
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  12. Richard Dick

    Richard Dick Full Member

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    It's pretty undeniable that it causes cancer. Doesn't mean everyone that uses it will get cancer though.
     
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  13. huntingground

    huntingground Kenstradamus Competitor

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    How did you come to this? Which studies?
     
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  14. milner575

    milner575 Top Contributor

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    you dont follow Ken’s journal then clearly :rofl:
     
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  15. milner575

    milner575 Top Contributor

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    #15
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