Epistan

Epistan

Half-life= cca 6 hours
Dosage= from 30 to 60 mg per day


-Epistan was misunderstood as anti-estrogen, as a substance that is able to reduce estrogens level in the body. This is methylated version of epithiostanol, which is a drug used for treatment of breast cancer at women. The true is that the Epistan is an analogue of anti-estrogenic drug used in Japan, but it’s really the substance that significantly reduces estrogens level in the body. It also quite shows a strong anabolic effects without water retention, what is quite big difference, because it really activates androgenic receptors. It was only designed to show the lowest rate of androgenic side effects. It was successful, because in practice it’s more anabolic than androgenic. So this is another DHT that is more anabolic and less toxic for the liver in comparison with Halodrol. However, in practice is compared to Oxandrolone due to the potential of muscle growth in good quality. Do not be lured on words of some dealers that is possible to compare it with Stanozol within muscle growth, definitely not.

-By the way, if I think, the Epistam directly affects in androgenic receptors without necessity of any conversion in the body, for example Halodrol. Why is then categorized in the group of prohormones and not directly in the group of steroids? Yes, I know, regarding the Epistan I always mention its degradation on deoxy methyltestosterone (Pheraplex), but this conversion is not necessary to be able to affect in androgenic receptor, so? Hm…well, but it meets the condition that is able to convert into another substance in the body, so I rather do not develop this idea. Let’s go to more important information.

Possible negative effects:

- I just want to point out that the actual Epistan must not cause water retention. You will find a few reviews in the foreign, which “say” that the Epistan quite caused water retention at some men. Why? Because they bought 17-alpha-methyl 2beta, 3-beta-epithio 5 alpha-androstan and not the actual Epistan, ie = 2a, 3a-epithio-17a-methyl-5a-androstan-17b-ol

- Estrogenic activity and cardiovascular system = as written for thousand time, substances that don’t convert on estrogens tend to have a bad impact on cholesterol, the Epistan is not exception. The Epistan decreases the level of good cholesterol (HDL), increases the level of bad cholesterol (LDL) and basically discomposes overall cholesterol. In the main, by its activity it really and very efficiently decreases any estrogenic symptoms in the body, because it will directly glue on estrogen receptor and deactivate it. It also glues estrogen cells on itself and may cause their death. This is really about very strong double effect that lasts a long time in the body! By this way is able to reduce the pumping effect within reason during the training what can also really interfere with anyone. Since many also evaluate the quality of taken substances depending on how they pump during the training. That’s definitely nonsense. Therefore I point out, even though you will not absolutely get pumped during the Epistan, so it should be! Or to be more exact, from the beginning should appear a significant muscle pump, though will have decreasing tendency by each week!

-Joint pain= many users may experience pain in joints while using the Epistan, which is a concomitant phenomenon in case of low estrogens level in the body. And since the Espistan not only occupies estrogen receptors, but can also kill estrogens, it’s a space that is created for this negative effect – PAIN IN JOINTS. Therefore it’s important to know that if you combine it with DHT derivatives or other substances, which bring quality muscle mass growth, this effect can be more deepened. That’s more than clear that each one of us will be differently sensible and someone will not experience pain in joints at all, while others can feel it just after 2-3 weeks of taking. Therefore, if does so and pain is more than unpleasant, it’s better to reduce the dose or immediately discontinue in taking the Epistan. It can be also taken with substance that converts into, and by this way to prevent given effect. For example, to take it together with Testosterone or also Methandienone in low doses.

IGF-1 level = it has quite big predisposition to reduce the IFG-1 levels through its strong anti-estrogenic activity.

-Androgenic activity= is slight how mentioned above. Acne, hair loss, growth of unwanted hair or enlargement of the prostate should not represent any real problem. Therefore is quite suitable also for women, as they mustn’t be worried abot virilization, I will write about it more in dosage. Beware, if I look at chemical name, the Epistan is 2a, 3a version of methylated DHT, and so we should theoretically categorize it to the DHT derivatives and with slight androgenic activity. Therefore I would be quite worried about hair loss at sensible individuals, but I repeat at SENSIBLE PEOPLE. On the other hand, the one who wants to take such substances or AAS, should accept that there will occur hair loss.

-Liver toxicity= is at much lower level than of Halodrol, but don’t underestimate it, since it belongs to the group of 17-AA substances! In the dose to 50 mg is not really heavy for the liver in any way, though is not needed to be ingenuous and expect representative values. Of course these will be in a negative meaning. However, I repeat that this is not any extreme. There are also such ones, who take the Epistan for the period of 8-10 weeks just due to low liver toxicity. Beware, basically in relation to AAS was solved a long time only liver toxicity, but here is also toxicity of cardiovascular system, which mustn’t be underestimated!!! However, the liver should handle long-term taking of the Epistan, due to HDL and LDL the time level of taking is shortened on 4-6 weeks.

-Impact on the production of own TST = is not so strong. It should never stop the production of own TST in case if used in adequate doses and adequate length. Beware, there is necessity to apply PCT after its taking is finished. In this substance many think about taking it in PCT, since it shows the effects of anti-estrogen as well as it brings anabolic effects. NO!!! Due to its negative effect on the production of own TST, theoretically it could actively prevent other anti-estrogens to make their positive function in increasing the production of own TST. Basically, if someone likes or not, its taking will always reduce the production of own TST at least of 50 %, though never on zero. What about sex? Libido? The first cca 2-3 weeks human will feel increased sexual appetite, but after will be appeared extremely low estrogens level together with decreased level of own TST and libido is decreased!

-Night sweating= many men complain night sweating during its taking, which usually intensifies with increasing dose, but there are also such ones, who don’t feel this effect at all.

Short summary of negatives= the Epistan is generally considered as quite safe substances, even though brings certain negative with itself. It’s not such toxical for the liver as for cardiovascular system, so it significantly disrupts cholesterol values. The production of own TST is only slightly reduced and therefore its recovery is very fast. It does not convert into estrogens and therefore is not necessary to be worried of gynecomastia or water retention. On the other hand, there is possible the occurrence of pain in joints. Hair loss occurs only in small cases and acne as well. However, there is need to think that it can be possible. Of course, all these negatives will lose after discontinuation.

Dosage

-In practice, the most common doses are 20 to 60 mg per day during 3-6 weeks. Basically just after the first two weeks, users note the first muscle gains and drainage. Since it has half-life cca 6 hours, it’s necessary to divide the daily dose into more times per day, as follows:

Dose 20 mg per day = 10 mg in the morning and 10 mg in the afternoon
Dose 30 mg per day = 10 mg in the morning + 10 mg in the afternoon + 10 mg in the evening
Dose 40 mg per day = 20 mg in the morning a 20 mg in the afternoon, or 20 mg in the morning + 10 mg in the afternoon + 10 mg in the evening
Dose 50 mg per day = 20 mg in the morning + 20 mg in the afternoon + 10 mg in the evening
Dose 60 mg per day = 20 mg in the morning + 20 mg in the afternoon + 20 mg in the evening or 30 mg in the morning + 30 mg in the evening

The dose in the cycles increases gradually, maximal chosen dose is never taken immediately from the beginning, but is necessary to reach it gradually. In practice it can look as follows:

1.Week = 20 mg of Epistan per day
2. Week = 20 mg of Epistan per day
3. Week = 30 mg of Epistan per day
4. Week = 30 mg of Epistan per day
5. Week = 40 mg of Epistan per day
6. Week = release

or higher doses for skilled courageous users
1. Week = 20 mg per day
2. Week = 30 mg per day
3. Week = 40 mg per day
4. Week = 50 mg per day
5. Week = 60 mg per day
6. Week = release

Short-term use with lower doses
1. Week = 20 mg per day
2. Week = 30 mg per day
3. Week = 40 mg per day
4. Week = 40 mg per day, where the release is from the half of the week

Short-term use with higher doses
1. Week = 30 mg per day
2. Week = 40 mg per day
3. Week = 50 mg per day
4. Week = 60 mg per day, where the release is from the half of the week

- Since it has only minimal androgenic activity, this substance is possible to be taken also by women. The daily dose will be within the range of 10 mg each or every another day. Beware, it’s necessary to consider that they are more likely to omit 1-2 menstrual cycles.
What can be combined with Epistan?

- It can be combined with any injectable AAS, either with TST, Nandrolone, Boldenone or Trenbolone, principally in the cycles when we expect quality muscle mass growth with minimal fat. You can go to the beginning of the cycle with goal to run the cycle faster or to finish the cycle, since it reduces estrogens level, so will remove the water from the body to a certain extent, ie will affect sharper. Therefore is logically more suitable to a diet cycles. Those who have problems with estrogenic affection, this substance is perfect for them to the cycles when is not only eliminated estrogenic activity, but also it brings muscle gains.

- Of course, there is no problem to combine it with any Sarms (Ligandrol, Andarine, Ostarine, Testolone...). The advantage is that in given combination there is no next negative intervention on the liver, since Sarms are very slight for the liver. By this way is often combined with Andarine to build really dry mass without water and with high rate of veiny look, where both substances will also support each other in fat loss.

- It’s also combined with prohormones, but here is necessary to modify the doses, because most of PH will have negative effect for the liver. Most often is combined just with Halodrol. However, in case that taken together, the doses of both substances must be decreased on 50 mg of Halodrol per day + 30 mg of Epistan per day. Of course, here are possible also other various combinations.
 
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